Robin A. Fairhurst : rechercher sur Z-Library

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1

A new route to secondary amines from bis-(alkoxymethyl)-alkylamines - the activation of an aminomethyl group and protection of the product by the same functional group

Martyn J. Earle, Robin A. Fairhurst, Harry Heaney, George Papageorgiou, Robert F. Wilkins

Journal:

Tetrahedron Letters

Année:

1990

Langue:

english

Fichier:

PDF, 269 KB

english, 1990

2

Mannich reactions of oxazolidines

Robin A. Fairhurst, Harry Heaney, George Papageorgiou, Robert F. Wilkins, Stephen C. Eyley

Journal:

Tetrahedron Letters

Année:

1989

Langue:

english

Fichier:

PDF, 281 KB

english, 1989

3

A Mild and Convenient High-Yield Alternative to the Protic Acid Catalysed Pictet-Spengler Synthesis of Tetrahydroisoquinolines

Cheung, Gi K., Earle, Martyn J., Fairhurst, Robin A., Heaney, Harry, Shuhaibar, Khamis F., Eyley, Stephen C., Ince, Francis

Journal:

Année:

1991

Fichier:

PDF, 206 KB

1991

4

Mannich reactiohs of aryltrialkylstannunes in aprotic solvents

Mark S. Cooper, Robin A. Fairhurst, Harry Heaney, George Papageorgiou, Robert F. Wilkins

Journal:

Année:

1989

Langue:

english

Fichier:

PDF, 768 KB

english, 1989

5

Bis-trimethylsilylacetamide: A reagent for the control of Friedel-Crafts alkylation reactions using methyl chloromethoxyacetate

Martyn J. Earle, Robin A. Fairhurst, Harry Heaney

Journal:

Tetrahedron Letters

Année:

1991

Langue:

english

Fichier:

PDF, 323 KB

english, 1991

6

Bromination of bicyclo[7.3.1]enediynes: Unusual rearrangement of the azabicyclo[7.3.1]enediyne dynemicin core structure

Philip Magnus, Robin Fairhurst, Shane Eisenbeis, Didier Grandjean

Journal:

Tetrahedron Letters

Année:

1995

Langue:

english

Fichier:

PDF, 245 KB

english, 1995

7

Long-chain formoterol analogues: an investigation into the effect of increasing amino-substituent chain length on the β2-adrenoceptor activity

Vahid Alikhani, David Beer, David Bentley, Ian Bruce, Bernard M. Cuenoud, Robin A. Fairhurst, Peter Gedeck, Sandra Haberthuer, Claire Hayden, Diana Janus, Lynne Jordan, Christine Lewis, Kirsty Smithie

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 300 KB

english, 2004

8

7-Azaindole-3-acetic acid derivatives: Potent and selective CRTh2 receptor antagonists

David A. Sandham, Claire Adcock, Kamlesh Bala, Lucy Barker, Zarin Brown, Gerald Dubois, David Budd, Brian Cox, Robin A. Fairhurst, Markus Furegati, Catherine Leblanc, Jodie Manini, Rachael Profit, Joh

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 996 KB

english, 2009

9

Synthesis and evaluation of two series of 4′-aza-carbocyclic nucleosides as adenosine A2A receptor agonists

David Beattie, Andrew Brearley, Zarin Brown, Steven J. Charlton, Brian Cox, Robin A. Fairhurst, John R. Fozard, Peter Gedeck, Paul Kirkham, Koremu Meja, Lana Nanson, James Neef, Helen Oakman, Gillian

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 348 KB

english, 2010

10

A physical properties based approach for the exploration of a 4-hydroxybenzothiazolone series of β2-adrenoceptor agonists as inhaled long-acting bronchodilators

David Beattie, Michelle Bradley, Andrew Brearley, Steven J. Charlton, Bernard M. Cuenoud, Robin A. Fairhurst, Peter Gedeck, Martin Gosling, Diana Janus, Darryl Jones, Christine Lewis, Clive McCarthy,

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 630 KB

english, 2010

11

The effect of sulphur dioxide on the mannich reactions of phenols

Robin A. Fairhurst, Harry Heaney, George Papageorgiou, Robert F. Wilkins

Journal:

Tetrahedron Letters

Année:

1988

Langue:

english

Fichier:

PDF, 249 KB

english, 1988

12

Efficacy is a contributing factor to the clinical onset of bronchodilation of inhaled β2-adrenoceptor agonists

Elizabeth M. Rosethorne, Robert J. Turner, Robin A. Fairhurst, Steven J. Charlton

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Année:

2010

Langue:

english

Fichier:

PDF, 262 KB

english, 2010

13

Potent and selective xanthine-based inhibitors of phosphodiesterase 5

Nichola J. Arnold, Ruth Arnold, David Beer, Gurdip Bhalay, Stephen P. Collingwood, Sarah Craig, Nicholas Devereux, Mark Dodds, Andrew R. Dunstan, Robin A. Fairhurst, David Farr, Joseph D. Fullerton, A

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 168 KB

english, 2007

14

Carnauba wax nanoparticles enhance strong systemic and mucosal cellular and humoral immune responses to HIV-gp140 antigen

Mauricio A. Arias, Andrew Loxley, Christy Eatmon, Griet Van Roey, David Fairhurst, Mark Mitchnick, Philip Dash, Tom Cole, Frank Wegmann, Quentin Sattentau, Robin Shattock

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 1.23 MB

english, 2011

15

An investigation into the structure–activity relationships associated with the systematic modification of the β2-adrenoceptor agonist indacaterol

Beattie, David, Beer, David, Bradley, Michelle E., Bruce, Ian, Charlton, Steven J., Cuenoud, Bernard M., Fairhurst, Robin A., Farr, David, Fozard, John R., Janus, Diana, Rosethorne, Elizabeth M., Sand

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2012

Langue:

english

Fichier:

PDF, 664 KB

english, 2012

16

The Identification of Indacaterol as an Ultralong-Acting Inhaled β 2 -Adrenoceptor Agonist

Baur, François, Beattie, David, Beer, David, Bentley, David, Bradley, Michelle, Bruce, Ian, Charlton, Steven J., Cuenoud, Bernard, Ernst, Roland, Fairhurst, Robin A., Faller, Bernard, Farr, David, Ke

Journal:

Journal of Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 1.17 MB

english, 2010

17

Short synthesis of the dynemicin core structure: unusual bridgehead enolate reactivity

Magnus, Philip, Parry, David, Iliadis, Theodore, Eisenbeis, Shane A., Fairhurst, Robin A.

Journal:

Journal of the Chemical Society Chemical Communications

Année:

1994

Langue:

english

Fichier:

PDF, 275 KB

english, 1994

18

Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation

Furet, Pascal, Guagnano, Vito, Fairhurst, Robin A., Imbach-Weese, Patricia, Bruce, Ian, Knapp, Mark, Fritsch, Christine, Blasco, Francesca, Blanz, Joachim, Aichholz, Reiner, Hamon, Jacques, Fabbro, Do

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2013

Langue:

english

Fichier:

PDF, 2.86 MB

english, 2013

19

Synthetic and Mechanistic Studies on the Azabicyclo[7.3.1]enediyne Core and Naphtho[2,3- h ]quinoline Portions of Dynemicin A

Magnus, Philip, Eisenbeis, Shane A., Fairhurst, Robin A., Iliadis, Theodore, Magnus, Nicholas A., Parry, David

Journal:

Journal of the American Chemical Society

Année:

1997

Langue:

english

Fichier:

PDF, 798 KB

english, 1997

20

Corrigendum to “Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation” [Bioorg. Med. Chem. Lett. 23 (2013) 3741–3748]

Furet, Pascal, Guagnano, Vito, Fairhurst, Robin A., Imbach-Weese, Patricia, Bruce, Ian, Knapp, Mark, Fritsch, Christine, Blasco, Francesca, Blanz, Joachim, Aichholz, Reiner, Hamon, Jacques, Fabbro, Do

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2013

Langue:

english

Fichier:

PDF, 233 KB

english, 2013

21

Synthesis of the Marine Sponge Derived β 2 -Adrenoceptor Agonist S1319

Fairhurst, Robin A., Janus, Diana, Lawrence, Annabel

Journal:

Organic Letters

Année:

2005

Langue:

english

Fichier:

PDF, 76 KB

english, 2005

22

Synthesis, structure and reactions of uridine 2′-C,3′-O-γ-butyrolactone: versatile intermediate for the synthesis of 2′-C-branched nucleosides

Lawrence, Anthony J., Pavey, John B. J., Chan, Mai-Yee, Fairhurst, Robin A., Collingwood, Stephen P., Fisher, Julie, Cosstick, Richard, O’Neil, Ian A.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Année:

1997

Langue:

english

Fichier:

PDF, 113 KB

english, 1997

23

Corrigenda

Wolleb-Gygi, Annemarie, Darbre, Tamis, Siljegovic, Vuk, Keese, Reinhart, Magnus, Philip, Parry, David, Iliadis, Theodore, Eisenbeis, Shane A., Fairhurst, Robin A., Hoskins, Bernard F., Robson, Richard

Journal:

Journal of the Chemical Society Chemical Communications

Année:

1995

Langue:

english

Fichier:

PDF, 67 KB

english, 1995

24

Synthesis and duplex stability of oligodeoxyribonucleotides containing a 2′→5′-amide linkage

Chan, Mai-Yee, Fairhurst, Robin A., Collingwood, Stephen P., Fisher, Julie, Arnold, John R. P., Cosstick, Richard, O’Neil, Ian A.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Année:

1999

Langue:

english

Fichier:

PDF, 176 KB

english, 1999

25

Relative rates of cycloaromatization of dynemicin azabicyclo[7.3.1]enediyne core structures. An unusual change in ?S?

Magnus, Philip, Fairhurst, Robin A.

Journal:

Journal of the Chemical Society Chemical Communications

Année:

1994

Langue:

english

Fichier:

PDF, 289 KB

english, 1994

26

Discovery of a novel tricyclic 4H-thiazolo[5′,4′:4,5]pyrano[2,3-c]pyridine-2-amino scaffold and its application in a PI3Kα inhibitor with high PI3K isoform selectivity and potent cellular activity

Gerspacher, Marc, Fairhurst, Robin A., Mah, Robert, Roehn-Carnemolla, Esther, Furet, Pascal, Fritsch, Christine, Guthy, Daniel A.

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2015

Langue:

english

Fichier:

PDF, 530 KB

english, 2015

27

Identification and optimisation of a 4′,5-bisthiazole series of selective phosphatidylinositol-3 kinase alpha inhibitors

Fairhurst, Robin A., Imbach-Weese, Patricia, Gerspacher, Marc, Caravatti, Giorgio, Furet, Pascal, Zoller, Thomas, Fritsch, Christine, Haasen, Dorothea, Trappe, Joerg, Guthy, Daniel A., Arz, Dorothee,

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2015

Langue:

english

Fichier:

PDF, 1.16 MB

english, 2015

28

Identification and optimisation of 4,5-dihydrobenzo[1,2-d:3,4-d]bisthiazole and 4,5-dihydrothiazolo[4,5-h]quinazoline series of selective phosphatidylinositol-3 kinase alpha inhibitors

Fairhurst, Robin A., Gerspacher, Marc, Imbach-Weese, Patricia, Mah, Robert, Caravatti, Giorgio, Furet, Pascal, Fritsch, Christine, Schnell, Christian, Blanz, Joachim, Blasco, Francesca, Desrayaud, San

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2015

Langue:

english

Fichier:

PDF, 1.27 MB

english, 2015

29

The identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone as an inhaled long-acting β2-adrenoceptor agonist

Arnold, Nicola, Beattie, David, Bradley, Michelle, Brearley, Andrew, Brown, Lyndon, Charlton, Steven J., Fairhurst, Robin A., Farr, David, Fozard, John, Fullerton, Joe, Gosling, Martin, Hatto, Julia,

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2014

Langue:

english

Fichier:

PDF, 897 KB

english, 2014

30

Detailed Procedures for the Preparation of Dimethoxycarbenium and Trimethyloxonium Tetrafluoroborate

Earle, Martyn J., Fairhurst, Robin A., Giles, Robert G., Heaney, Harry

Journal:

Année:

1991

Fichier:

PDF, 100 KB

1991

31

Nucleic Acid Containing 3′-C-P-N-5′ Ethyl Phosphonamidate Ester and 2′-Methoxy Modifications in Combination; Synthesis and Hybridisation Properties

Fairhurst, Robin A., Collingwood, Stephen P., Lambert, David, Wissler, Elke

Journal:

Année:

2002

Langue:

english

Fichier:

PDF, 71 KB

english, 2002

32

Tandem and Stepwise Reactions of β-(3,4-Dialkoxyphenyl)ethylamine Bis(aminol) Ethers in Syntheses of N -Arylmethyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines: A Synthesis of Sendaverine Methyl Ether

Cooper, Mark S., Earle, Martyn J., Fairhurst, Robin A., Heaney, Harry, Papageorgiou, George, Wilkins, Robert F.

Journal:

Année:

1990

Fichier:

PDF, 148 KB

1990

33

A New Synthesis of Primary Amines Using tert -Butylamine as an Ammonia Equivalent: The Triflic Acid Catalysed Removal of N - tert -Butyl Groups from Carbamates

Earle, Martyn J., Fairhurst, Robin A., Heaney, Harry, Papageorgiou, George

Journal:

Année:

1990

Fichier:

PDF, 130 KB

1990

34

Diastereoselective Reactions of Trialkylsilyl Enol Ethers with Acyliminium Ions

Brown, David S., Earle, Martyn J., Fairhurst, Robin A., Heaney, Harry, Papageorgiou, George, Wilkins, Robert F., Eyley, Stephen C.

Journal:

Année:

1990

Fichier:

PDF, 183 KB

1990

35

Diastereoselective Reactions of Trialkylsilyl Enol Ethers with Acyliminium Ions

Brown, David S., Earle, Martyn J., Fairhurst, Robin A., Heaney, Harry, Papageorgiou, George, Wilkins, Robert F., Eyley, Stephen C.

Journal:

Année:

1990

Fichier:

PDF, 183 KB

1990

36

Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors

Fairhurst, Robin A., Marsilje, Thomas H., Stutz, Stefan, Boos, Andreas, Niklaus, Michel, Chen, Bei, Jiang, Songchun, Lu, Wenshuo, Furet, Pascal, McCarthy, Clive, Stauffer, Frédéric, Guagnano, Vito, Va

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2016

Langue:

english

Fichier:

PDF, 1.43 MB

english, 2016

37

Uncoupling the structure-activity relationships of β2 adrenergic receptor ligands from membrane binding

Dickson, Callum J., Hornak, Viktor, Velez-Vega, Camilo, Mckay, Daniel J. J., Reilly, John, Sandham, David A., Shaw, Duncan, Fairhurst, Robin A., Charlton, Steven J., Sykes, David A., Pearlstein, Rober

Journal:

Journal of Medicinal Chemistry

Année:

2016

Langue:

english

Fichier:

PDF, 1.40 MB

english, 2016

38

Increasing metabolic stability via the deuterium kinetic isotope effect: An example from a proline-amide-urea aminothiazole series of phosphatidylinositol-3 kinase alpha inhibitors

Fairhurst, Robin A., Caravatti, Giorgio, Guagnano, Vito, Aichholz, Reiner, Blanz, Joachim, Blasco, Francesca, Wipfli, Peter, Fritsch, Christine, Maira, Sauveur-Michel, Schnell, Christian, Seiler, Fran

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2016

Langue:

english

Fichier:

PDF, 1.11 MB

english, 2016

39

2-Formylpyridyl-ureas as highly-selective reversible-covalent inhibitors of fibroblast growth factor receptor 4

Knoepfel, Thomas, Furet, Pascal, Mah, Robert, Buschmann, Nicole, Leblanc, Catherine, Ripoche, Sebastien, Graus-Porta, Diana, Wartmann, Markus, Galuba, Inga, Fairhurst, Robin A.

Journal:

ACS Medicinal Chemistry Letters

Année:

2018

Langue:

english

Fichier:

PDF, 462 KB

english, 2018

40

Discovery of Roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4

Fairhurst, Robin A., Knoepfel, Thomas, Buschmann, Nicole, Leblanc, Catherine, Mah, Robert, Todorov, Milen, Nimsgern, Pierre, Ripoche, Sebastien, Niklaus, Michel, Warin, Nicolas, Luu, Van Huy, Madoerin

Journal:

Journal of Medicinal Chemistry

Année:

2020

Fichier:

PDF, 1.93 MB

2020

41

Correction to â2-Formylpyridyl Ureas as Highly Selective Reversible-Covalent Inhibitors of Fibroblast Growth Factor Receptor 4â

Knoepfel, Thomas, Furet, Pascal, Mah, Robert, Buschmann, Nicole, Leblanc, Catherine, Ripoche, Sebastien, Graus-Porta, Diana, Wartmann, Markus, Galuba, Inga, Fairhurst, Robin A.

Journal:

ACS Medicinal Chemistry Letters

Année:

2020

Fichier:

PDF, 290 KB

2020